专利名称：BENZAMIDE DERIVATIVES发明人：SHIGEHIRO ASANO,NAONORI
IMAZAKI,MASAFUMI KITANO,TATSUYAFUJIBAYASHI
申请号：AU2003220935申请日：20030328公开号：AU2003220935A1公开日：20031013
摘要：A compound represented by formula (1): wherein X is a single bond or asubstituted or unsubstituted lower alkylene group; Z is a saturated or unsaturatedmonocyclic hydrocarbon ring group or the like; and each of R<1>, R<2>, R<3> andR<4>, which may be the same or different, is a hydrogen atom, a halogen atom, a nitrogroup, a cyano group, a carboxyl group, a substituted or unsubstituted alkyl group, orthe like, a prodrug of said compound, or a pharmaceutically acceptable salt of saidcompound or prodrug has inhibitory effect on Rho kinase and hence is useful for treatingdiseases which are such that morbidity due to them is expected to be improved byinhibition of Rho kinase and secondary effects such as inhibition of the Na<+>/H<+>exchange transport system caused by the Rho kinase inhibition, for example,hypertension.
申请人：SUMITOMO PHARMACEUTICALS COMPANY, LIMITED.
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