食管癌放疗患者营养管理(详见光盘)

肿瘤代谢与营养电子杂志  2018年3月9日第5卷第1期        Electron J Metab Nutr Cancer，Mar. 9，2018，Vol. 5，No. 1

cisplatin to mitochondrial DNA of Chinese hamster ovary cells. Mutat Res. 1995;346(4):221-230.

69. Carew JS, Zhou Y, Albitar M, et al. Mitochondrial DNA mutations

in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications. Leukemia. 2003;17(8):1437-1447.70. Chatterjee A, Chang X, Nagpal JK, et al. Targeting human

8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. Oncogene. 2008;27(26):3710-3720.

71. Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations

produce 2-hydroxyglutarate. Nature. 2009;462(7274):739-744.72. Neuzil J, Dong LF, Ramanathapuram L, et al. Vitamin E analogues

as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria. Mol Aspects Med. 2007;28(5-6):607-5. 73. Ralph SJ, Neuzil J. Mitochondria as targets for cancer therapy. Mol

Nutr Food Res. 2009;53:9-28.

74. Morisaki T, Katano M. Mitochondria-targeting therapeutic

strategies for overcoming chemoresistance and progression of cancer. Curr Med Chem. 2003;10(23):2517-2521.

75.邓丽, 饶本强. 线粒体代谢: 清热解毒中药复方JC724抗

肿瘤机制. 肿瘤代谢与营养电子杂志. 2017;12( 4 ):247-252.76. Waters LS, Minesinger BK, Wiltrout ME, et al. Eukaryotic

translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol Mol Biol Rev. 2009;73(1):134-1.

收稿日期: 2018-02-23本文编辑:王晓琳

copy number and lung cancer risk in a prospective cohort study. Carcinogenesis. 2010;31(5):847-849.

60. Fliss MS, Usadel H, Caballero OL, et al. Facile detection of

mitochondrial DNA mutations in tumors and bodily fluids. Science. 2000;287(60):2017-2019.

61. Dasgupta S, Koch R, Westra WH, et al. Mitochondrial DNA mutation

in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res. 2010;3(9):1205-1211. 62. Ha PK, Tong BC, Westra WH, et al. Mitochondrial C-tract

alteration in premalignantlesions of the head and neck: a marker for progression and clonal proliferation. Clin Cancer Res. 2002;8(7):2260-2265.

63. Rigoli L, Di Bella C, Verginelli F, et al. Histological heterogeneity

and somatic mtDNA mutations in gastric intraepithelial neoplasia. Mod Pathol. 2008;21(6):733-741.

. Parrella P, Xiao Y, Fliss M, et al. Detection of mitochondrial DNA

mutations in primary breast cancer and fine-needle aspirates. Cancer Res. 2001;61(20):7623-7626.

65. Tan D, Goerlitz DS, Dumitrescu RG, et al. Associations between

cigarette smoking and mitochondrial DNA abnormalities in buccal cells. Carcinogenesis. 2008;29(6):1170-1177.

66. He L, Luo L, Proctor SJ, et al. Somatic mitochondrial DNA

mutations in adult-onset leukaemia. Leukemia. 2003;17(12):2487-2491.

67. Maitra A, Cohen Y, Gillespie SE, et al. The human mitochip: a

high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res. 2004;14(5):812-819.

68. Olivero OA, Semino C, Kassim A, et al. Preferential binding of

·视频·

食管癌放疗患者营养管理（详见光盘）

程玉峰（山东大学齐鲁医院）

食管癌患者营养状态与预后：针对143例接受三维适形放疗以及顺铂、5-FU为基础的食管癌化疗患者，采用体质指数（body mass index，BMI）、血浆白蛋白、体重下降百分比评估治疗前患者营养状况，计算营养风险指数（nutritional risk index，NRI），并根据得分分成3级，通过多因素分析发现：NRI较高的患者生存期延长、局部复发率低，治疗前患者的NRI可作为的预后因素。

食管癌放疗患者的营养支持研究：针对61接受新辅助放化疗或姑息性放化疗的消化道肿瘤患者，包括食管癌、胃癌、食管胃交界处肿瘤，随机分为实验组和对照组，实验组由营养顾问小组指导饮食；对照组采取常规护理。结果发现：营养顾问小组介入能有效维持住院患者治疗期间的营养状态，其中摄入充足的EPA有助于防止患者体重下降。

食管癌放疗患者营养支持的方法研究：针对91名接受以顺铂、5-FU为基础的新辅助化疗的食管癌患者，采用肠外、肠内(经口或经鼻饲管进食）两种营养治疗方式。结果发现：两组患者化疗前后体重及血清白蛋白变化无明显差异；对化疗的敏感性无明显差异；但是肠内营养组化疗副反应发生率明显降低。